| ORIGINAL ARTICLE |
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Introduction: The
study of benign prostatic hyperplasia (BPH) is intricate and its
complete understanding is yet to be achieved. The hormones testosterone
and dihydrotestosterone have a permissive and important role in male
fertility. Growth factors and other hormones like estrogens and factors
that may contribute to the development of BPH.
Objective: This study investigated the ameliorating potential of
polyherbal leave extract of Stinging nesttle, Vernonia amygdalina, Milk
thistle and roots of Musa Paradisiaca on Testosterone
Propionate-Induced Benign prostatic hyperplasia in male wistar rats.
Methods: A
total of 36 male rats were used in this study. They were grouped into 6
groups of 6 rats each. Benign prostate hyperplasia was induced in the
rats using the intraperitoneal administration of 5 mg/kg testosterone
propionate injection subcutaneously and 1 hour later treated with
polyherbal extract for 28 consecutive days. Semen sample was collected
for spermatozoa quality, morphology and gonadosomatic indices using
standard protocols.
Results: The
study showed that the induction of BPH brought about some adverse
effect on spermatozoa proportion, quality, normal spermatozoa and
testicular and prostate weight relative to normal control. Sperm
abnormalities like those with bent mid-piece were seen. The findings
showed that the administration of SVMM extract had a significant
positive impact on the sperm cell abnormalities, significant
reduction in testicular and prostate weight thus, leading to the
restoration of the sperm cell morphology and potentially improving
fertility.
Conclusions:
These findings demonstrated that the use of SVMM can reduce the harmful
effects of Testosterone Propionate-Induced Benign prostatic hyperplasia
(BPH) and enhance fertility by restoring the quality semen and sperm
morphology to their normal state in rats.
