TY  - JOUR
AU  - Asadu, Chidimma Lilian
AU  - Uroko, Robert Ikechukwu
AU  - Ubenyi, Stanley Mary
T1  - Evaluation of Spermatozoa Quality, Differential Sperm Morphology and Gonadosomatic Indices of Benign Prostatic Hyperplasia Induced Rats Treated with Polyherbal Extract
JO  - Journal of Stress Physiology & Biochemistry
Y1  - 2025/december
VL  - 21
IS  - 4
SP  - 253
EP  - 262
UR  - http://www.jspb.ru/issues/2025/N4/JSPB_2025_4_253-262.pdf
KW  - Benign prostatic hyperplasia
KW  - Milk thistle
KW  - Musa paradisiacal
KW  - Stinging nettle
KW  - Testosterone Propionate
KW  - Vernonia amygdalina
U1  - 1997-0838
N2  - Introduction: The study of benign prostatic hyperplasia (BPH) is intricate and its complete understanding is yet to be achieved. The hormones testosterone and dihydrotestosterone have a permissive and important role in male fertility. Growth factors and other hormones like estrogens and factors that may contribute to the development of BPH. Objective: This study investigated the ameliorating potential of polyherbal leave extract of Stinging nesttle, Vernonia amygdalina, Milk thistle and roots of Musa Paradisiaca on Testosterone Propionate-Induced Benign prostatic hyperplasia in male wistar rats. Methods: A total of 36 male rats were used in this study. They were grouped into 6 groups of 6 rats each. Benign prostate hyperplasia was induced in the rats using the intraperitoneal administration of 5 mg/kg testosterone propionate injection subcutaneously and 1 hour later treated with polyherbal extract for 28 consecutive days. Semen sample was collected for spermatozoa quality, morphology and gonadosomatic indices using standard protocols. Results: The study showed that the induction of BPH brought about some adverse effect on spermatozoa proportion, quality, normal spermatozoa and testicular and prostate weight relative to normal control. Sperm abnormalities like those with bent mid-piece were seen. The findings showed that the administration of SVMM extract had a significant positive impact on the sperm cell abnormalities, significant reduction in testicular and prostate weight thus, leading to the restoration of the sperm cell morphology and potentially improving fertility. Conclusions: These findings demonstrated that the use of SVMM can reduce the harmful effects of Testosterone Propionate-Induced Benign prostatic hyperplasia (BPH) and enhance fertility by restoring the quality semen and sperm morphology to their normal state in rats.
ER  -