Journal of Stress Physiology & Biochemistry, Vol. 21 No. 3 2025, pp. 128-135 ISSN 1997-0838
Original Text Copyright (cc) 2025  by  Shobana and Nayagam



ORIGINAL ARTICLE
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In silico Docking Studies of Calendoflavobioside of Calendula officinalis Linn. against Matrix Metallo Proteinase 8 and 12 on Wound Healing

Shobana Gunasekaran*, Agnel Arul John Nayagam

1 PG & Research Department of Biochemistry, Srimad Andavan Arts & Science college, Tiruchirappalli, Tamil Nadu, India

*E-Mail:  shobana.gunasekaran9@gmail.com


Received February 25, 2025


Bioactive compounds are a rich source of preventive substances for many diseases. In the present study was attempt to evaluate the in silico docking studies of calendoflavobioside of Calendula officinalis Linn. on wound healing. The compound calendoflavobioside were screened for the wound healing biomarker matrix metallo proteinases 8 and 12 by molecular docking. The result of the study indicates that calendoflavobioside has good affinity with MMP 8(-3.00kcal/mol) and MMP 12(-3.08kcal/mol).

Key words:   Metallo Proteinase 8, Metallo Proteinase 12, Calendula officinalis, Calendoflavobioside, Molecular docking

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