Journal of Stress Physiology &
Biochemistry, Vol. 9 No. 1
2013, pp. 106-112 ISSN 1997-0838
Original Text Copyright (cc) 2013 by Tandon, Bhakar, Pande, Karki,
Negi and Khanna
ORIGINAL
ARTICLE
Data source : Google Scholar
QueryDate : 2016-12-24
Cites : 3
Oxidative Stress Induced Lipid
Peroxidation And DNA Adduct Formation In The Pathogenesis Of Multiple
Myeloma And Lymphoma
Ravi Tandon1, Mahima
Bhakar1, Deepti Pande2, Kanchan Karki2,
Reena Negi2, H.D. Khanna2* 1 Department of Medicine, Institute of Medical
Sciences, Banaras Hindu University, Varanasi, India -221005 2 Department of Biophysics, Institute of Medical Sciences,
Banaras Hindu University, Varanasi, India -221005
Tel.: 91-9450710446
*E-Mail: hdkhanna@yahoo.co.in
Received October 13, 2012
Objective: To access the oxidative
stress status by quantification of byproducts generated during lipid
peroxidation and DNA breakdown products generated during DNA damage in
the blood serum of multiple myeloma and lymphoma patients. Material & Methods: Case
control study comprised of 40 patients of multiple myeloma and 20
patients of lymphoma along with 20 age and sex-matched healthy subjects
as controls. Levels of Malondialdehyde and 8-hydroxy-2-deoxy-Guanosine
were measured to study the oxidative stress status in the study
subjects. Results: The level of
markers of DNA damage and lipid peroxidation were found to be raised
significantly in the study subjects in comparison to healthy controls.
The results indicate oxidative stress and DNA damage activity increase
progressively with the progression of disease. Conclusion: Oxidative stress
causes DNA damage and Lipid peroxidation which results in the formation
of DNA adducts leading to mutations thereby indicate the role of
oxidative stress in the pathogenesis of multiple myeloma and lymphoma.
