TY  - JOUR
AB  - Objective: To access the oxidative stress status by quantification of byproducts generated during lipid peroxidation and DNA breakdown products generated during DNA damage in the blood serum of multiple myeloma and lymphoma patients.
Material & Methods: Case control study comprised of 40 patients of multiple myeloma and 20 patients of lymphoma along with 20 age and sex-matched healthy subjects as controls. Levels of Malondialdehyde and 8-hydroxy-2-deoxy-Guanosine were measured to study the oxidative stress status in the study subjects.
Results:  The level of markers of DNA damage and lipid peroxidation were found to be raised significantly in the study subjects in comparison to healthy controls. The results indicate oxidative stress and DNA damage activity increase progressively with the progression of disease.
Conclusion: Oxidative stress causes DNA damage and Lipid peroxidation which results in the formation of DNA adducts leading to mutations thereby indicate the role of oxidative stress in the pathogenesis of multiple myeloma and lymphoma.
AU  - Tandon, Ravi
AU  - Bhakar, Mahima
AU  - Pande, Deepti
AU  - Karki, Kanchan
AU  - Negi, Reena
AU  - Khanna, H. D.
DA  - 2013
ET  - 2013
KW  - Oxidative Stress
Malondialdehyde
8-hydroxy-2-deoxy-Guanosine
Multiple myeloma
Lymphoma
M1  - 1
M3  - ORIGINAL ARTICLE
PY  - 2013
SE  - 106
SN  - 1997-0838
SP  - 106-112
ST  - Oxidative Stress Induced Lipid Peroxidation And DNA Adduct Formation In The Pathogenesis Of Multiple Myeloma And Lymphoma
T2  - Journal of Stress Physiology & Biochemistry
TI  - Oxidative Stress Induced Lipid Peroxidation And DNA Adduct Formation In The Pathogenesis Of Multiple Myeloma And Lymphoma
UR  - http://www.jspb.ru/issues/2013/N1/JSPB_2013_1_106-112.pdf
VL  - 9
ID  - 11
ER  -