TY  - JOUR
AU  - Kayumov, A. R.
AU  - Iskhakova, Z. I.
AU  - Safina, R. R.
AU  - Gilfanov, I. R.
AU  - Nikitina, L. E.
AU  - Lisovskaya, S. A.
AU  - Guseva, G. B.
AU  - Eremeeva, Yu. V.
AU  - Antina, E. V.
T1  - Potential of Diiodo-BODIPY Meso-Acid and Its Esters for Photodynamic Therapy of Microbial Biofilms
JO  - Journal of Stress Physiology & Biochemistry
Y1  - 2026/august
VL  - 22
IS  - 3
SP  - 135
EP  - 142
UR  - http://www.jspb.ru/issues/2026/N3/JSPB_2026_3_135-142.pdf
KW  - bacterial biofilms
KW  - photodynamic therapy
KW  - terpenoids
KW  - BODIPY
U1  - 1997-0838
N2  - Background. Nowadays, there is an increasing number of infectious diseases in humans and animals associated with formation of microbial biofilms, including fungal-bacterial consortia. Due to the diffusional barrier of the biofilm matrix, the biofilm-embedded cells are characterized by increased resistance to antimicrobials and the host immune system. In this study we assessed the ability of diiod derivatives of BODIPY luminophores to eradicate mono- and dual species communities of S. aureus and C. albicans.
Results. The diiodo-BODIPY meso-butanoic acid, and its conjugate with isobornanethioethyl or pinanyl, were tested. The diiod derivative of BODIPY in the form of acid, when irradiated at 530 nm at concentrations of 2 μg/ml, resulted in complete cell death of planktonic staphylococci, and at 16 μg/ml completely eradicated its biofilm, but was non effective against Candida biofilms. Partial cell death was observed against S. aureus in mixed S. aureus and C. albicans biofilms at 8 μg/ml. The compound was able to penetrate biofilms as resolved by CLSM, but moderate antimicrobial activity was observed.
Conclusion. The diiod-BODIPY acid of BODIPY luminophores are of interest for photodynamic therapy of staphylococcal biofilms. Their conjugation with terpenoids increases the rate of biofilm penetration, but the selection of a terpene radical is necessary to enhance antimicrobial activity.
ER  -