ORIGINAL ARTICLE

The Effect of Physiological NO Donor on the State of Erythrocytes Energy Metabolism of Rat under Thermal Trauma

The aim of this work is estimation of action of dinitrosyl iron complexes (DNIC) on rats’ blood energy metabolism at combined thermal trauma. We studied 30 Wistar rats, divided into 3 groups: intact (n=10), control (n=10) and main (n=10) group. We modeled combined thermal trauma (skin burn + thermoinhalation injury) in animals of control and main groups. Rats of control group got a infusions of sodium chloride solution (n=10) every day. Rats of main group got infusions of DNIC in sodium chloride solution. In blood samples we studied activity of lactate dehydrogenase in direct and reverse reaction, lactate level and coefficients of substrate provision and energy reactions balance. It was stated that DNIC clearly normalized erythrocytes energy metabolism from third day after trauma.