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The aim of the work was to evaluate
the effect of free and deposited in the composition of dinitrosyl iron
(DNIC) complexes of nitrogen monoxide on the crystallogenic properties
and metabolic parameters of blood serum in vitro.
Material and methods. The
effect of various forms of nitric oxide (NO-containing gas mixtures
from the Plason apparatus (initial or tenfold diluted gas flow – 80 and
800 ppm) and an experimental nitric oxide generator (20-100 ppm),
glutathione-containing DNIC) on the crystallization of blood serum was
studied in vitro. Shifts in the crystallogenic properties of biofluid
were compared with changes in other physical and chemical parameters.
Results. It has been shown that
different forms of nitric oxide have different effects on the
crystallogenic properties of blood serum in vitro, and the feature of
the action of DNIC is the most pronounced stimulation of the
structuring of biofluid (an increase in crystallizability by 1.28
times, and the structure index by 1.47 times), combined with a decrease
in the destruction of elements (by 1.95 times) and an expansion of the
marginal zone (in 1.56 times). It was revealed that these shifts
correlate with the dynamics of other metabolic and physico-chemical
parameters.
