ORIGINAL ARTICLE

Evaluation of Hepatoprotective Activity of Dolichandrone atrovirens Leaves Stem Extract against CCl₄‐Induced Hepatic Damage in Wistar Rats

Background: Exposure to environmental contaminants, including carbon tetrachloride (CCl₄), induces hepatic damage. Certain extracts from Dolichandrone atrovirens (Bignoniaceae) protect against such damage.

Results: This research examines the preventive effects of hydroalcoholic extracts from the leaves of D. atrovirens (HE-DA) versus liver damage produced by CCl₄ in rats. HE-DA was delivered orally to rats at three dosages (100, 200, and 300 mg/kg) in conjunction with CCl₄ (1 mL/kg in olive oil) for three weeks. Lipid profile indices, peroxidation levels, and antioxidant activity were assessed in rats' liver tissue. TC, TG, PL, FFA, and LDL levels were reduced. Hepatic malondialdehyde concentrations were decreased, and antioxidant activities were modified in rats treated with HE-DA. Histopathological analysis of the liver revealed that HE-DA therapy decreased fatty degeneration, cytoplasmic vacuolisation, and necrosis.

Conclusion: HE-DA had a protective effect against CCl₄-induced hepatotoxicity in rats, whose antioxidant capabilities may have mediated this effect.