ORIGINAL ARTICLE

Effect of Monosodium Glutamate on Hepatic and Renal Functions in Albino Rat

Our present study aimed to evaluate the impact of monosodium glutamate (MSG) on hepatic and renal functions in albino rats, administering doses of 35, 70, and 105 mg/kg body weight daily for 17 days. Significant changes in body weight and the relative weight of liver and kidneys were observed. Notable findings included increased serum glutamic oxaloacetic transaminase (SGOT) activity, reduced total protein content, and elevated total cholesterol and glucose levels in liver and kidney tissues. Additionally, kidney function was adversely affected, indicated by increased serum urea and creatinine levels. These results suggest that MSG induces oxidative stress, leading to hepatic and renal dysfunction.