ORIGINAL ARTICLE

Variations in Hematological Parameters During the Treatment of Carbon Tetrachloride-induced Hepatotoxicity with Three Different Polyherbal Formulations

Background: Many active chemicals have been identified in therapeutic plants, which are a valuable source of medicine. Many medicinal herbs, including hepatotoxicity, have been utilized to treat a variety of illnesses under the traditional medical system of India. Your liver may be harmed by toxic liver disorders. It's referred to as toxic hepatitis or hepatotoxicity. If you don't get care, it can result in severe symptoms or damage to your liver. Hepatotoxicity may be brought on by drugs, herbal supplements, chemicals, solvents, and alcohol. The goal of the current study was to assess how multiherbal formulations affected hematological markers in albino rats who were experiencing hepatotoxicity caused by carbon tetrachloride. Five plant extracts (Curcuma longa, Allium sativum, Phyllanthus emblica, Solenum nigrum, and Ocimum tenuiflorum) were combined to create three distinct formulations. Blood samples were taken from each rat and examined using conventional procedures (parameters) following daily administration of multiherbal formulations at a dose of 200 mg/kg b.wt. and the reference medicine (Silymarin) at a dose of 25 mg/kg b.wt. for 7, 14, and 21 days, respectively. Measurements included hemoglobin, PCV, DLC, TLC, ESR, and PLT count.

Results: When hepatotoxicity-induced rats were compared to normal controls, there was a substantial (p<0.01) rise in TLC, neutrophil%, and ESR and a significant (p<0.01) decrease in Hb, lymphocyte%, PLT count, and PCV. In contrast to the standard group and normal control group, treatment of these experimental rats with three different formulations resulted in a substantial (p<0.01) decrease in TLC, neutrophil%, and ESR and a significant (p<0.01) increase in Hb, lymphocyte%, PLT count, and PCV.

Conclusion: Based on the results of this investigation, we were able to determine that, out of the three formulations, formulation I (Curcuma longa, Allium sativum, and Solenum nigram) was the most effective in the management of toxicity caused by carbon tetrachloride.