Journal of Stress Physiology & Biochemistry, Vol. 19, No. 4, 2023, pp. 163-177       ISSN 1997-0838
Original Text Copyright (cc) 2023 by  Moola, Shobana and Janani

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PPAR gamma Agonists – Plant Compounds

Anil Kumar Moola 1, Shobana G. 2 and C. Janani 3*

Department of Biotechnology, Aditya Degree College, Lakshmi Narayana Nagar, Kakinada, Andhra Pradesh, India - 533 003
2  Department of Biochemistry, Srimad Andavan Arts and Science College, Tiruchirappalli,. Tamil Nadu, India - 622 005
3  Department of Biotechnology, Srimad Andavan Arts and Science College, Tiruchirappalli,. Tamil Nadu, India – 622 005


Received August 17, 2023

The nuclear receptor peroxisome proliferator activated receptor-gamma (PPARg) controls adipocyte differentiation, as well as lipid metabolism and insulin sensitivity. As a result, PPARg is a promising candidate gene for a variety of human diseases, such as obesity and type 2 diabetes. Hyperglycemia associated with the metabolic syndrome and type 2 diabetes is treated with agonists of the nuclear receptor PPARg. The PPARg agonists of the thiazolidinedione type, despite being effective in normalizing blood glucose levels, have serious side effects, making the discovery of novel ligands extremely important. Natural products have historically proven to be a promising source of structures for drug development, and recent research has focused on the PPARg-activating potential of a wide range of natural products derived from traditionally used medicinal plants or dietary sources. This review highlights recent studies that have advanced our understanding of this receptor's role in metabolism, with a focus on the effects of compounds in the plant.

Key words:    PPAR gamma, type 2 diabetes, natural products

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