Journal of Stress Physiology & Biochemistry, Vol. 19 No. 4 2023, pp. 5-14 ISSN 1997-0838
Original Text Copyright (cc) 2023 by Abdulkadir, Ayo, Isa, Dawud, Dimka-Bashok and Jafar

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Taurine and/or Camel Milk Mitigates Haemolysis and Malondialdehyde Concentration in Alzheimer Rats

Teslim S. Abdulkadir1∗, Joseph O. Ayo2, Ahmed Sherif Isa1, Fatima A. Dawud1, Lengnen Dimka-Bashok3 and Fatima Y. Jafar4

Department of Human Physiology, Faculty of Basic Medical Sciences, Ahmadu Bello University, Zaria, Nigeria.
2 Department of Veterinary Physiology, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, Nigeria.
3 Department of Human Physiology, Faculty of Basic Medical Sciences, University of Jos, Jos, Nigeria.
4 Department of Human Physiology, Faculty of Basic Medical Science, Kaduna State University, Kaduna, Nigeria

         ORCID number: 0000-0002-4644-8885

Received April 15, 2023

Alzheimer’s disease (AD) is a devastating neurodegenerative disease, affecting all age groups. Malondialdehyde (MDA) concentration and haemolysis are important oxidative stress biomarkers, implicated in the pathogenesis of AD. The study aimed to evaluate taurine, camel milk (CM) and their combined effects on MDA concentration and haemolysis in AD rats. The animal groupings were; Normal saline (0.2 mL/mg bw); AlCl3 (100 mg/kg); CM (33 mL/kg); Taurine (50 mg/kg); AlCl3 (100 mg/kg) + CM (33 mL/kg); AlCl3 (100 mg/kg) + Taurine (50 mg/kg) and AlCl3 (100 mg/kg) + CM (33 mL/kg) + Taurine (50 mg/kg). Concentration of MDA and percentage haemolysis were determined for all groups. At 0.5% NaCl, haemolysis in AD rats (64.00 1.27 %) was higher (p < 0.05) than in AD + CM (51.50 2.96 %) and AD + CM + Taurine (52.00 1.53%) rats. MDA concentration was lowered (p < 0.05) in taurine-treated rats than controls, but it increased with haemolysis in AD rats compared to other groups. Taurine and/or CM exhibited antioxidant activity by decreasing haemolysis and MDA concentration in AD groups, and may be beneficial in mitigating AD-induced oxidative stress changes.

Key words:    Aluminum chloride, camel milk, malondialdehyde, taurine, oxidative stress

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