Journal of Stress Physiology & Biochemistry, Vol. 17 No. 2 2021, pp. 66-78 ISSN 1997-0838
Original Text Copyright (cc) 2021 by   Janani, Sundararajan, Moola and Ranjitha Kumari

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Antidiabetic Activity of Methanolic Leaves Extract of Transformed Soybean Plantlets in Streptozotocin (STZ) Induced Diabetic Rats

C. Janani1*, B. Sundararajan2, Anil Kumar Moola3 and B. D. Ranjitha Kumari2

1 Department of Biotechnology, Srimad Andavan Arts and Science College, Tiruchirappalli,. Tamil Nadu, India
2 Department of Botany, Bharathidasan University, Tiruchirappalli, Tamil Nadu, India
3 Department of Biotechnology, Aditya Degree and PG College, Lakshmi Narayana Nagar, Kakinada, Andhra Pradesh, India - 533 003


Received January 11, 2021

Diabetes is expanding quickly around the world, which produces unsettling influences in the digestion of sugar, protein, and lipid. Proof suggested that the normal drugs beginning from plant source may speak to a socially applicable correlative treatment for diabetes. This examination planned to assess the cell reinforcement and antidiabetic exercises of the methanolic leaves extracts of transformed and non-transformed soybean in streptozotocin induced diabetic rats. The enlistment of diabetes with a single dose of streptozotocin and afterward the rats are treated with single dose of methanolic leaves extracts of transformed and non-transformed soybean (50 mg/kg body weight) for 21 days. Glibenclamide is utilized as a standard medication (0.5 mg/kg b.w.). The degree of glucose, lipid peroxidation, glutathione peroxidase, decreased glutathione, superoxide dismutase and catalase were resolved in diabetic rats after the treatment. The administration of methanolic leaves extracts of transformed soybean saw a critical reduction in levels of glucose and lipid peroxidation. The significant increased was found in glutathione, glutathione peroxidase, superoxide dismutase and catalase levels in the liver when contrasted and diabetic control rats after medicines. The examination demonstrated that the methanolic leaves concentrates of transformed soybean rewarded rats successfully manage the cell reinforcement exercises in STZ induced diabetic rewarded rats. This examination presumed that the transformed (PPARγ gamma) crude methanolic leaves extracts have huge hypoglycemic, hypolipidemic and cell antioxidant potential.

Key words:    Antioxidant, Diabetes, Glibenclamide, Streptozotocin 

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