Journal of Stress Physiology & Biochemistry, Vol. 13 No. 2 2017, pp. 19-25 ISSN 1997-0838
Original Text Copyright (cc) 2017 by  Voloshchuk and Kopylchuk

Full text in PDF Download to Citation Manager Permanent url

Cellular Immunity State of Protein-deficient Rats with the Toxic Liver Injury

O.N. Voloshchuk, G.P. Kopylchuk

Institute of Biology, Chemistry and Bioresources of Chernovtsi national university named by Yurii Fedkovych, Biochemistry and biotechnology department, Chernovtsi, Ukraine

*E-Mail: о

Received February 16, 2017

Studies on the role of immunity mechanisms in the emergence and maintenance of inflammatory and destructive processes in the liver under toxic hepatitis and nutrient deficiency are topical. The aim of research – to study the quantitative content and functional activity of leukocytes under the conditions of acetaminophen-induced hepatitis on the background of nutritional protein deficiency.

The most pronounced changes in cell-mediated immunity are observed in protein-deficient animals with toxic hepatitis. The pronounced defects of both specific and non-specific cellular immunity were manifested by the leukocytosis, increase number of segmented neutrophils in blood serum against decrease their phagocytic index and phagocytic number, reduction of total lymphocyte number, and simultaneously lowering of T- and B-lymphocytes was established under the conditions of acetaminophen-induced hepatotoxicity on the background of protein deficiency. Installed changes indicate the defective formation of functional immunity state which can manifest by decrease the body’s ability to carry out the reaction of cellular and humoral immunity.

Research results may be used for the rationale of therapeutic approaches to the elimination and correction of the consequences of immunological status disturbances under the conditions of acetaminophen-induced hepatitis, aggravated by the alimentary protein deprivation.

Key words:    alimentary deprivation of protein, immunity, leucocytes, toxic hepatitis

Back to issue content
интернет статистика
Free blog