Effect of Hypothermic Exposure (+2°C, In Vitro) on the Radical Activity of Neutrophils

Polezhaeva, T.V.; Khudyakov, A.N.; Solomina, O.N.; Zaitseva, O.O.; Paturova, I.G.; Utemov, S.V.; Vetoschkin, K.A.

Journal of Stress Physiology & Biochemistry, Vol. 13 No. 1 2017, pp. 15-22 ISSN 1997-0838
Original Text Copyright (cc) 2017 by Polezhaeva, Khudyakov, Solomina, Zaitseva, Paturova, Utemov and Vetoschkin

ORIGINAL ARTICLE

Effect of Hypothermic Exposure (+2°C, In Vitro) on the Radical Activity of Neutrophils

T.V. Polezhaeva ¹*, A.N. Khudyakov ¹, O.N. Solomina ¹, O.O. Zaitseva ¹, I.G. Paturova ², S.V. Utemov ³, K.A. Vetoschkin ³

¹ Physiology Institute at the Komi Scientific Center, 167982, Syktyvkar, Pervomayskaya str., 50, Russia
² Kirov State Medical Academy, 610027, Kirov, Karl Marx str., 112, Russia
³ Kirov Research Institute of Haematology and Blood Transfusion, 610027, Kirov, Krasnoarmeyskaya str., 72, Russia

*E-Mail: ddic@yandex.ru

Received November 15, 2016

The possibility of using the hypothermic impact (+ 2° C, in vitro) as a non-drug stimulator of cell immunity was studied. Using chemiluminescence method found that in women with physiological pregnancy the radical response of neutrophils to a foreign object enhanced after cold exposure. The mechanism of radical activity is inhibited in childbirth and the threat of premature birth. In the acute period of cold injury the immunological (radical) reactivity of neutrophils venous blood of men lowered. The restoration of adaptive mechanisms starts with treatment and require subsequent rehabilitation period. This is confirmed by the weak radical response of neutrophils to a foreign object after hypothermic exposure.

Key words: hypothermic effect, radical activity of neutrophils, physiological pregnancy, childbirth, threat of premature birth, cold injury