TY  - JOUR
AU  - Zhu, Wan-long
AU  - Zhang, Di
AU  - Zheng, Jia
AU  - Zhang, Lin
AU  - Liu, Jin-hu
AU  - Cheng, Jin
AU  - Wang, Zheng-kun
T1  - Comparison of Nonshivering Thermogenesis Induced by Norepinephrine Stress in Tree Shrews
JO  - Journal of Stress Physiology & Biochemistry
Y1  - 2013
VL  - 9
IS  - 4
SP  - 180
EP  - 186
UR  - http://www.jspb.ru/issues/2013/N4/JSPB_2013_4_180-186.pdf

KW  - Tupaia belangeri; Nonshivering thermogenesis; Norepinephrine




N1  - Owner: Алексей
N1  - Added to JabRef: 2013.10.11
N2  - Nonshivering thermogenesis (NST)is an important thermogenic mechanism for small mammals. Quantitative  measurement  of  NST  is  usually  stimulated  by  injection  of  norepinephrine.  The injection dosage of norepinephrine (NE) is critical for eliciting the maximum NST. Three empirical equations of NE dosages were often referenced in previous studies: (1) NE (mg / kg)= 2.53W-0.4; (2) NE(mg/kg) = 3.3W-0.458 and (3) NE(mg/kg)= 6.6W-0.458. In the present study , we used tree shrews (Tupaia belangeri) as experiment subjects to test the effects of the three dosages of NE on NST. Results showed that all the three dosages of NE could induce the maximum NST for T. belangeri. No significant differences were found in NST among groups and the NST was respectively 2.63±0.12 (formula 1), 2.66±0. 11 (formula 2) and 2.78±0.15 (formula 3). However, when injected with NE dosage from formula 3, the increase of body temperatures was significantly higher than the other two NE dosages (increased 1.5±0. 1 oC (formula 3), 0.8±0. 2 oC (formula 2), and 0.6±0. 1 oC (formula 1),  respectively).  In  order  to  prevent  the  death  because  of  hyperthermia,  formula  1  or  2  is recommended to be used.
ER  -