Journal of Stress Physiology & Biochemistry, Vol. 9 No. 4 2013, pp. 122-131 ISSN 1997-0838
Original Text Copyright (cc) 2013 by   Dachanidze, Burjanadze, Kuchukashvili, Menabde, Koshoridze



ORIGINAL ARTICLE
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Functioning of the Antioxidant System under Psycho-Emotional Stress

Natalia Dachanidze*, George Burjanadze, Zurab Kuchukashvili, Ketevan Menabde, Nana Koshoridze

Department of Biology, Faculty of Exact and Natural Sciences, I. Javakhishvili Tbilisi State University, Tbilisi 0128, Georgia

*E-Mail:  n.dachanidze@yahoo.com


Received June 20, 2013


It was studied intensity of lipid peroxidation and activity of enzymes from antioxidant system in blood plasma and cardiac muscle cells among laboratory rats under 40 days of isolation and violation of  diurnal  cycle.  The  received  data  show  that  at  the  background  of  quantitative changes in NO there also take place changes in the intensity of lipid peroxidation process, indicated  by  quantitative  change  in  the  concentration  of  Malone  dialdehyde  and  diene conjugates, including Malonedialdehyde and marked with a reduced activity of antioxidant system enzymes, such as catalase and superoxide dismutase activity. Based on the results, we proposed that psychological stress is one of the factors contributing to the development of various cardiac diseases.

Key words:   Antioxidant system, psycho-emotional stress, superoxide-dismutase, catalase, nitric oxide

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