Journal of Stress Physiology &
Biochemistry, Vol. 9 No. 1
2013, pp. 96-105 ISSN 1997-0838
Original Text Copyright (cc) 2013 by Sadeghi Niaraki, Nabavizadeh,
Vaezi, Alizadeh, Nahrevanian, Moslehi and Azizian
ORIGINAL
ARTICLE
Data source : Google Scholar
QueryDate : 2016-12-24
Cites : 4
Protective Effect of Ghrelin
on Sodium Valproate-induced Liver Injury in Rat
Mandana Sadeghi Niaraki1,
Fatemeh Nabavizadeh2*, Gholam H. Vaezi3, Ali M.
Alizadeh4, Hossein Nahrevanian5, Azam Moslehi2,
Saleh Azizian4 1 Department of biology, Damghan branch, Islamic Azad
University, Damghan, Iran. 2 Department of physiology, Tehran University of Medicale
Sciences and Health Services, Tehran, Iran. 3 Department of biology, Islamic Azad University, Damghan
Branch, Semnan, Iran. 4 Cancer Research Center, Tehran University of medical
sciences, Tehran, Iran. 5 Department of Parasitoligy, Pasteur Institute of Iran,
Tehran 13164, Iran.
*E-Mail: nabavizadeh2000@yahoo.com
Received October 9, 2012
Ghrelin is a peptide
that has protective effects on many tissues injury. It has
anti-inflammatory and anti-oxidant effects. Sodium valproate is widely
used anticonvuisant and anti-depression drug with hepatotoxic side
effects. The aim of this study was to evaluated the protective role of
ghrelin in liver toxicity due to sodium valproate overdose. Eighteen
rats were used in this study and divided in to three groups,
containing: control, sodium valproate, and sodium valproate and ghrelin
groups. Nitric oxide (NO), prostaglandin E2 (PGE2) and hepatic enzymes
AST (aspartate aminotransferase) and ALT (alanine aminotransferase),
were assessed and histologic study of liver were performed as
indicators of liver damage following sodium valproate toxicity. This
study showed the ghrelin decreased ALT and AST to the normal level. Our
results show that ghrelin significantly increased NO metabolites and
decreased PGE2 level comparison with sodium valproate group, but had no
significant change compared to the control group. we showed that
ghrelin administration inhibited liver injury in rats due to sodium
valproate toxicity.
