TY  - JOUR
AB  - Ghrelin (GHR) is a peptide that has protective effects on many tissues injury. It has anti-inflammatory and anti-oxidant effects. Isoniazid (INH) a widely used antituberculosis drug, has hepatotoxic side effect. The aim of this study was to evaluate the protective role of ghrelin in liver toxicity due to isoniazid. Eighteen male rats were used in this study and divided in to three groups. Including: control, isoniazid, isoniazid and ghrelin groups. Nitric oxide (NO), prostaglandin E2 (PGE2), and hepatic enzymes, ALT (alanine aminotransferase), AST (aspartate aminotransferase), ALK(alkaline phosphatas), were assessed and histologic study of liver were performed as indicators of liver damage following isoniazid toxicity. Ghrelin significantly increased NO metabolites and decreased PGE2 level comparison with INH group, but had no significant change compared to the control group.  This study showed that ghrelin administration inhibited liver injury in rats due to isoniazid toxicity. The liver protective role of ghrelin may be mediated at least in part by its anti-inflammatory effect.
AU  - Kheyabany, Shadi Sar Kheyr
AU  - Nabavizadeh, Fatemeh
AU  - Vaezi, Gholam Hassan
AU  - Alizadeh, Ali Mohammad
AU  - Nahrevanian, Hossein
AU  - Moslehi, Azam
AU  - Azizian, Saleh
DA  - 2013
ET  - 2013
KW  - Ghrelin
Isoniazid (INH)
liver injury
nitric oxide (NO)
prostaglandin E2 (PGE2)
M1  - 1
M3  - ORIGINAL ARTICLE
PY  - 2013
SE  - 273
SN  - 1997-0838
SP  - 273-282
ST  - Protective Effect of Ghrelin on Isoniazid-induced Liver Injury in Rat
T2  - Journal of Stress Physiology & Biochemistry
TI  - Protective Effect of Ghrelin on Isoniazid-induced Liver Injury in Rat
UR  - http://www.jspb.ru/issues/2013/N1/JSPB_2013_1_273-282.pdf
VL  - 9
ID  - 23
ER  -