TY  - JOUR
AB  - Effect of stress on pre-pubertal ovarian follicular development was studied. Fifteen day old female rats were administered under stress (exposed to maternal separation; 6 hours/day) from post-natal day 15 to 21 for 7 days, and appropriate controls were maintained. The time of exposure was randomly changed every day during light phase (7AM to 7 PM) of the day to avoid habituation. There was a significant decrease in serum estrogen levels on post-natal day 21 in stress group rats compared to controls indicating stress response in these rats. However, mean number of healthy follicles in all categories of follicles were significantly lower in stressed rats compared to controls. Concomitant with these changes, mean number of atreitic follicles showed an increase over control values in stressed rats. In contrast administration of Naltrexone (5μg NTX/rat/day), Mifepristone (1 μg MP/rat/day), FSH (10 IU FSH/rat/day) with stressed the significant increases in the relative weight of ovary, uterus, fallopian tube, body weight and the mean number of healthy follicles in the ovary compared to the controls. In the ovary treatment of stressed did not affect primordial follicles. Primordial follicles were reduced in number significantly in the ovary of controls and treated groups when compared with the initial controls whereas there was no significant variation among the controls and the treated groups. The results indicate that stress dose not interfere with the progress of pre-pubertal follicular development. However, it causes increased loss of follicles by atretia.
AU  - Abdullah, K. H.
ET  - 2012
KW  - Naltrexone
Mifepristone
FSH
Stress
Follicular development
Ovary
atretia
prepubertal
M1  - 3
M3  - ORIGINAL ARTICLE
PY  - 2012
SN  - 1997-0838
SP  - 82-98
ST  - Effect of stress hormone antagonists on ovarian follicular development in pre-pubertal rat
T2  - Journal of Stress Physiology & Biochemistry
TI  - Effect of stress hormone antagonists on ovarian follicular development in pre-pubertal rat
UR  - http://www.jspb.ru/issues/2012/N3/JSPB_2012_3_82-98.pdf
VL  - 8
ID  - 40
ER  -