Journal of Stress Physiology & Biochemistry, Vol. 7, No. 4,
2011, pp. 88- 96. ISSN 1997-0838
Original Text Copyright (cc) 2011 by Burjanadze, Menabde, Gavashelidze, Kuchukasvili, Koshoridze
ORIGINAL
ARTICLE
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Functional Status of Mitochondrial Pore in the Brain of Laboratory Rats Subjected to Prolonged Emotional Stress
Burjanadze G., Menabde K., Gavashelidze M., Kuchukasvili Z., Koshoridze N.
Faculty of Exact and Natural Sciences, Iv. Javakhishvili Tbilisi State University, Tbilisi, University St. 13, 0128, Georgia E-mail: ketimenabde@yahoo.com
Received August 21, 2011
We have studied the
functional status of the mitochondrial membrane pore in the brain of
laboratory rats under the stress caused by 30-day isolation and
violation of diurnal cycles. It has been established that the
functional status of the MMTP changes under the stress. Particularly,
the MPTP is activated as the pore opens affected by an increased
concentration of cytoplasmic Са2+ and reduced content of mitochondrial Са2+. It has been suggested that the Са2+-induced
opening of the pore is a result of the intensified oxidative processes
in the brain, as a result of energy deficiency and a reduced activity
of anti-oxidative enzymes.
