TY  - JOUR
AB  - The objective of the study was to find out whether or not exposure to a stressor after an initial  stressful experience augments stress response.  Antioxidant status was determined by measuring changes in the activities of the hepatic free radical scavenging enzymes viz, superoxide dismutase (SOD), glutathione-S-transferase (GST), glucose-6-phosphate-dehydrogenase (G6PDH) and catalase (CAT) and levels of hepatic malondialdehyde (MDA) following exposure to 1 h restraint (RS) and after a gap of 4 h to forced swimming exercise (FS) in rats. The activities of hepatic CAT, SOD,  G6PDH and GST were significantly reduced 2 h after RS compared to controls and 4 h after FS the  activities of CAT and G6PDH remained at lower levels i.e. they were similar to those found after RS ,  whereas SOD and GST showed further significant decrease compared to those found after RS. On the other hand the MDA levels, indicative of lipid peroxidation were significantly increased after RS and showed further significant increase after FS. The results reveal that after initial stressful experience,  the stress response is augmented due to exposure to another stressor whereas the system does not get  habituated to stress exposure.
AU  - Devaki, M.
AU  - Nirupama, R.
AU  - Yajurvedi, H. N.
ET  - 2011
KW  - CAT
G6PDH
GPx
GST
MDA
oxidative stress
SOD
stress
M1  - 2
M3  - ORIGINAL ARTICLE
PY  - 2011
SN  - 1997-0838
SP  - 139-147
ST  - Reduced antioxidant status for prolonged period due to repeated stress exposure in rat
T2  - Journal of Stress Physiology & Biochemistry
TI  - Reduced antioxidant status for prolonged period due to repeated stress exposure in rat
UR  - http://www.jspb.ru/issues/2011/N2/JSPB_2011_2_139-147.pdf
VL  - 7
ID  - 126
ER  -